When ingested, mitragynine breaks down into another chemical called 7-hydroxymitragynine, which also influences the body and is an important subject of research.22 Learn more: How do kratom compounds work rein the brain?

NIDA is a biomedical research organization and does not provide personalized medical advice, treatment, counseling, or legal consultation. Information provided by NIDA is not a substitute for professional medical care or legal consultation.

NIDA also supports preclinical research to better understand how multiple kratom compounds produce complex pharmacological and behavioral effects, to evaluate kratom as a potential therapy for opioid use disorder and to investigate the chemistry and biology of kratom-derived compounds for their use as therapeutic drugs and as research tools. (Tümpel Could kratom Beryllium used as medicine?)

Researchers are lautlos learning how kratom and kratom compounds affect the body, as well as how short- and long-term kratom use may impact health. While evidence is quickly evolving, early studies have revealed important information about how the drug works.

They noted that 11 people had been hospitalized with salmonella illness linked to kratom. Those Weltgesundheitsorganisation fell ill consumed kratom rein pills, powder or tea.

NIDA and its partners conduct and support research evaluating kratom and related compounds as potential treatments for chronic pain and for opioid withdrawal and opioid use disorder. Learn more: How is NIDA advancing research on kratom?

Effects on pregnancy are not well understood. Very little research is available on kratom use before, during and after pregnancy, but there have been reports of opioid-like neonatal abstinence syndrome in infants born to women World health organization regularly use kratom.37 Learn more: How does kratom use affect pregnancy?

Teich more NIDA-funded projects related to kratom, and learn more click here about clinical trials involving kratom.

The FDA's analysis from February 2018 included 44 reported deaths associated with the use of kratom. Deaths reported by the FDA have involved one person who had no historical or toxicologic evidence of opioid use, except for kratom.

The DEA noted the responses but said that it intended to go forward with the listing; a spokesman said: "We can't rely upon public opinion and anecdotal evidence. We have to rely upon science."[110] rein October 2016, the DEA withdrew its notice of intent while inviting public comments over a Nachprüfung period ending on December 1, 2016.

Although it was a federally legal dietary supplement, kratom was not approved as a therapeutic Detektiv rein the United States due to the poor quality of the research.[12][10] hinein November 2017, the FDA cited serious concerns over the Absatzwirtschaft and effects (including death) associated with the use of kratom in the United States, stating that "There is no reliable evidence to support the use of kratom as a treatment for opioid use disorder; there are currently no FDA-approved therapeutic uses of kratom.

25 More research is needed in this area to assess the safety of using kratom rein combination with other substances.

Currently, kratom is not included in standard drug screens rein the US. Kratom tests are available for screening but are not widely available.

Because the withdrawal effects of kratom are often reported to Beryllium less severe than those associated with traditional opioids,[12] some people use kratom rein the attempt to manage opioid use disorder,[34] though no clinical trials have been done supporting this use. As of 2018[update], there have been no formal trials to study the efficacy or safety of kratom to treat opioid addiction.[8] Kratom is not approved for this or any other medical use.